Retrograde Coronary Sinus Infusion (RCSI)
Approach for targeted delivery of biological molecules to the heart
Retrograde Coronary Sinus Infusion (RCSI) is a procedure used to deliver biological molecules to the heart.
In RCSI, a balloon catheter is inserted into the coronary sinus and left inflated for a time to occlude the coronary sinus and facilitate the circulation of the therapeutic in the heart. Therapeutic molecules are infused through the catheter. Once the infusion is complete, the balloon catheter is deflated and removed. The RCSI approach allows for delivery via capillary filtration increased by hydrostatic and osmotic pressures. The efficiency of transduction is dependent on the volume and time of infusion.